Modification of the 4-Hydroxyphenylacetate-3-hydroxylase Substrate Pocket to Increase Activity towards Resveratrol

Modification of the 4-Hydroxyphenylacetate-3-hydroxylase Substrate Pocket to Increase Activity towards Resveratrol

4-Hydroxyphenylacetate-3-hydroxylase (4HPA3H; EC 1.14.14.9) is a heterodimeric flavin-dependent monooxygenase complex that catalyzes the <i>ortho</i>-hydroxylation of resveratrol to produce piceatannol. Piceatannol has various health benefits and valuable applications in food, medicine,...

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Bibliographic Details
Main Authors: Qianchao Zhang, Yuning Jin, Kai Yang, Sheng Hu, Changjiang Lv, Jun Huang, Jiaqi Mei, Weirui Zhao, Lehe Mei
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
4-hydroxyphenylacetate-3-hydroxylase
piceatannol
substrate pocket
semi-rational design
<i>ortho</i>-hydroxylation
Online Access:https://www.mdpi.com/1420-3049/28/14/5602

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https://www.mdpi.com/1420-3049/28/14/5602

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