Polymorphisms in the mitochondrial DNA control region and frailty in older adults.

Polymorphisms in the mitochondrial DNA control region and frailty in older adults.

Mitochondria contribute to the dynamics of cellular metabolism, the production of reactive oxygen species, and apoptotic pathways. Consequently, mitochondrial function has been hypothesized to influence functional decline and vulnerability to disease in later life. Mitochondrial genetic variation ma...

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Bibliographic Details
Main Authors: Ann Z Moore, Mary L Biggs, Amy Matteini, Ashley O'Connor, Sarah McGuire, Brock A Beamer, M Danielle Fallin, Linda P Fried, Jeremy Walston, Aravinda Chakravarti, Dan E Arking
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2883558?pdf=render

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http://europepmc.org/articles/PMC2883558?pdf=render

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