A novel and potent dihydroorotate dehydrogenase inhibitor suppresses the proliferation of colorectal cancer by inducing mitochondrial dysfunction and DNA damage

A novel and potent dihydroorotate dehydrogenase inhibitor suppresses the proliferation of colorectal cancer by inducing mitochondrial dysfunction and DNA damage

Abstract Dihydroorotate dehydrogenase (DHODH) is a quite attractive target in cancer therapy. Nevertheless, the antitumor effects of DHODH inhibitors against colorectal cancer (CRC) and the underlying mechanism have seldom been studied. Here, we explored the anti‐CRC efficacy of M62, a novel and pot...

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Bibliographic Details
Main Authors: Xiaowei Yang, Chungen Li, Kun Gou, Xiaocong Liu, Yue Zhou, Jiao Zou, Qiang Chen, Youfu Luo, Yinglan Zhao
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:MedComm – Oncology
Subjects:
colorectal cancer
DHODH inhibitors
DNA damage
mitochondrial dysfunction
Online Access:https://doi.org/10.1002/mog2.6

Internet

https://doi.org/10.1002/mog2.6

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