Inhibition of Prostate Cancer Bone Metastasis by Synthetic TF Antigen Mimic/Galectin-3 Inhibitor Lactulose-l-Leucine

Currently incurable, prostate cancer metastasis has a remarkable ability to spread to the skeleton. Previous studies demonstrated that interactions mediated by the cancer-associated Thomsen-Friedenreich glycoantigen (TF-Ag) and the carbohydrate-binding protein galectin-3 play an important role in se...

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Bibliographic Details
Main Authors: Olga V. Glinskii, Sudha Sud, Valeri V. Mossine, Thomas P. Mawhinney, Douglas C. Anthony, Gennadi V. Glinsky, Kenneth J. Pienta, Vladislav V. Glinsky
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800790