Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release.

Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release.

Knockout serum replacement (KOSR) is a nutrient supplement commonly used to replace serum for culturing stem cells. We show here that KOSR has pro-survival activity in chronic myelogenous leukemia (CML) cells transformed by the BCR-ABL oncogene. Inhibitors of BCR-ABL tyrosine kinase kill CML cells b...

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Bibliographic Details
Main Authors: Yuki Ishii, May Keu Nhiayi, Edison Tse, Jonathan Cheng, Michele Massimino, Donald L Durden, Paolo Vigneri, Jean Y J Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4608728?pdf=render

Internet

http://europepmc.org/articles/PMC4608728?pdf=render

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