Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model

Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model

Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), which is involved in collagen synthesis and deposition, had elevated expression in colorectal ca...

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Bibliographic Details
Main Authors: Sumit Agarwal, Michael Behring, Hyung-Gyoon Kim, Prachi Bajpai, Balabhadrapatruni V.S.K. Chakravarthi, Nirzari Gupta, Amr Elkholy, Sameer Al Diffalha, Sooryanarayana Varambally, Upender Manne
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320301030

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http://www.sciencedirect.com/science/article/pii/S1936523320301030

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