Crucial role of chelatable iron in silver nanoparticles induced DNA damage and cytotoxicity

Crucial role of chelatable iron in silver nanoparticles induced DNA damage and cytotoxicity

Damage to mitochondria and subsequent ROS leakage is a commonly accepted mechanism of nanoparticle toxicity. However, malfunction of mitochondria results in generation of superoxide anion radical (O2•-), which due to the relatively low chemical reactivity is rather unlikely to cause harmful effects...

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Bibliographic Details
Main Authors: Agnieszka Grzelak, Maria Wojewódzka, Sylwia Meczynska-Wielgosz, Mariusz Zuberek, Dominika Wojciechowska, Marcin Kruszewski
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
Nanoparticle toxicity
ROS generation
Mitochondria
Iron
Fenton reaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717309138

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http://www.sciencedirect.com/science/article/pii/S2213231717309138

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