Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury

Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury

Lipid peroxidation-derived aldehydes, such as acrolein, the most reactive aldehyde, have emerged as key culprits in sustaining post-spinal cord injury (SCI) secondary pathologies leading to functional loss. Strong evidence suggests that mitochondrial aldehyde dehydrogenase-2 (ALDH2), a key oxidoredu...

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Bibliographic Details
Main Authors: Seth A Herr, Liangqin Shi, Thomas Gianaris, Yucheng Jiao, Siyuan Sun, Nick Race, Scott Shapiro, Riyi Shi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
acrolein; acrolein-lysine adduct; alda-1; enzymatic catalyst; lipid peroxidation; mitochondrial aldehyde dehydrogenase-2; neurotrauma; oxidative stress; reactive aldehydes; spinal cord contusion
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=7;spage=1505;epage=1511;aulast=Herr

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=7;spage=1505;epage=1511;aulast=Herr

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