The link between inhibition of PI3K signaling, induction of autophagy, and elimination of organelles to form the lens organelle-free zone
The elimination of organelles to create the lens organelle-free zone (OFZ) is a macroautophagy/autophagy-dependent mechanism that occurs without causing cell death. This process is essential to the ability of the lens to focus incoming images on the retina, as the presence of these organelles would...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Autophagy Reports |
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| Online Access: | http://dx.doi.org/10.1080/27694127.2022.2080315 |
| _version_ | 1797685727094374400 |
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| author | A. Sue Menko |
| author_facet | A. Sue Menko |
| author_sort | A. Sue Menko |
| collection | DOAJ |
| description | The elimination of organelles to create the lens organelle-free zone (OFZ) is a macroautophagy/autophagy-dependent mechanism that occurs without causing cell death. This process is essential to the ability of the lens to focus incoming images on the retina, as the presence of these organelles would interfere with lens refraction of light and impair vision. Therefore, organelles are removed from differentiating lens fiber cells during development, their elimination beginning with the non-nuclear organelles in the central lens fiber cells, and expanding over time to the neighboring fiber cells in the lens cortex. The removal of fiber cell nuclei lags behind that of non-nuclear organelles, following the same spatiotemporal patterning. We find that removal of organelles to form the OFZ depends on the induction of autophagy through the inhibition of phosphoinositide 3-kinase (PI3K) signaling. Abbreviation OFZ– organelle-free zone |
| first_indexed | 2024-03-12T00:55:30Z |
| format | Article |
| id | doaj.art-ba8c613aa6ef4e7ba49336c0bee22da4 |
| institution | Directory Open Access Journal |
| issn | 2769-4127 |
| language | English |
| last_indexed | 2024-03-12T00:55:30Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj.art-ba8c613aa6ef4e7ba49336c0bee22da42023-09-14T13:24:40ZengTaylor & Francis GroupAutophagy Reports2769-41272022-12-011123824110.1080/27694127.2022.20803152080315The link between inhibition of PI3K signaling, induction of autophagy, and elimination of organelles to form the lens organelle-free zoneA. Sue Menko0Thomas Jefferson UniversityThe elimination of organelles to create the lens organelle-free zone (OFZ) is a macroautophagy/autophagy-dependent mechanism that occurs without causing cell death. This process is essential to the ability of the lens to focus incoming images on the retina, as the presence of these organelles would interfere with lens refraction of light and impair vision. Therefore, organelles are removed from differentiating lens fiber cells during development, their elimination beginning with the non-nuclear organelles in the central lens fiber cells, and expanding over time to the neighboring fiber cells in the lens cortex. The removal of fiber cell nuclei lags behind that of non-nuclear organelles, following the same spatiotemporal patterning. We find that removal of organelles to form the OFZ depends on the induction of autophagy through the inhibition of phosphoinositide 3-kinase (PI3K) signaling. Abbreviation OFZ– organelle-free zonehttp://dx.doi.org/10.1080/27694127.2022.2080315aktautophagydevelopmentdifferentiationlensnucleiorganellesorganelle-free zone (ofz)pi3ksignaling |
| spellingShingle | A. Sue Menko The link between inhibition of PI3K signaling, induction of autophagy, and elimination of organelles to form the lens organelle-free zone Autophagy Reports akt autophagy development differentiation lens nuclei organelles organelle-free zone (ofz) pi3k signaling |
| title | The link between inhibition of PI3K signaling, induction of autophagy, and elimination of organelles to form the lens organelle-free zone |
| title_full | The link between inhibition of PI3K signaling, induction of autophagy, and elimination of organelles to form the lens organelle-free zone |
| title_fullStr | The link between inhibition of PI3K signaling, induction of autophagy, and elimination of organelles to form the lens organelle-free zone |
| title_full_unstemmed | The link between inhibition of PI3K signaling, induction of autophagy, and elimination of organelles to form the lens organelle-free zone |
| title_short | The link between inhibition of PI3K signaling, induction of autophagy, and elimination of organelles to form the lens organelle-free zone |
| title_sort | link between inhibition of pi3k signaling induction of autophagy and elimination of organelles to form the lens organelle free zone |
| topic | akt autophagy development differentiation lens nuclei organelles organelle-free zone (ofz) pi3k signaling |
| url | http://dx.doi.org/10.1080/27694127.2022.2080315 |
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