Cloning and Characterization of <i>Trypanosoma congolense</i> and <i>T. vivax</i> Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis

Cloning and Characterization of <i>Trypanosoma congolense</i> and <i>T. vivax</i> Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis

African Animal Trypanosomiasis (AAT), caused predominantly by <i>Trypanosoma brucei brucei</i>, <i>T. vivax</i> and <i>T. congolense</i>, is a fatal livestock disease throughout Sub-Saharan Africa. Treatment options are very limited and threatened by resistance. T...

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Bibliographic Details
Main Authors: Marzuq A. Ungogo, Mustafa M. Aldfer, Manal J. Natto, Hainan Zhuang, Robyn Chisholm, Katy Walsh, MarieClaire McGee, Kayhan Ilbeigi, Jamal Ibrahim Asseri, Richard J. S. Burchmore, Guy Caljon, Serge Van Calenbergh, Harry P. De Koning
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Trypanosoma vivax</i>
<i>Trypanosoma congolense</i>
nucleoside antimetabolite
adenosine transporter
nucleoside transporter
animal trypanosomiasis
Online Access:https://www.mdpi.com/1422-0067/24/4/3144

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https://www.mdpi.com/1422-0067/24/4/3144

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