Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities

Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities

A series of 26 novel 1-(7-chloroquinolin-4-yl)-4-nitro-1H-pyrazoles bearing a dichloromethyl and an amino or thio moiety at C3 and C5 has been prepared in yields up to 72% from the reaction of 1,1-bisazolyl-, 1-azolyl-1-amino-, and 1-thioperchloro-2-nitrobuta-1,3-dienes with 7-chloro-4-hydrazinylqui...

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Bibliographic Details
Main Authors: Viktor A. Zapol’skii, Isabell Berneburg, Ursula Bilitewski, Melissa Dillenberger, Katja Becker, Stefan Jungwirth, Aditya Shekhar, Bastian Krueger, Dieter E. Kaufmann
Format: Article
Language:English
Published: Beilstein-Institut 2022-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
antimalarial activity
anti-sars-cov-2 activity
chloroquine
2-nitroperchlorobutadiene
nucleophilic vinylic substitution
1h-pyrazoles
Online Access:https://doi.org/10.3762/bjoc.18.54

Internet

https://doi.org/10.3762/bjoc.18.54

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