Acetylcholine protects mesenteric arteries against hypoxia/reoxygenation injury via inhibiting calcium-sensing receptor

Acetylcholine protects mesenteric arteries against hypoxia/reoxygenation injury via inhibiting calcium-sensing receptor

The Ca2+-sensing receptor (CaSR) plays an important role in regulating vascular tone. In the present study, we investigated the positive effects of the vagal neurotransmitter acetylcholine by suppressing CaSR activation in mesenteric arteries exposed to hypoxia/reoxygenation (H/R). The artery rings...

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Bibliographic Details
Main Authors: Ming Zhao, Xi He, Yong-Hua Yang, Xiao-Jiang Yu, Xue-Yuan Bi, Yang Yang, Man Xu, Xing-Zhu Lu, Qiang Sun, Wei-Jin Zang
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Journal of Pharmacological Sciences
Subjects:
Acetylcholine
Hypoxia/reoxygenation
Calcium-sensing receptor
Vascular function
Mesenteric artery
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315000730

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http://www.sciencedirect.com/science/article/pii/S1347861315000730

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