Correction of Hyperglycemia in Diabetic Mice Transplanted with Reversibly Immortalized Pancreatic β Cells Controlled by the tet-on Regulatory System
Pancreatic β cell lines may offer an abundant source of cells for β-cell replacement in type I diabetes. Using regulatory elements of the bacterial tetracycline (tet) operon for conditional expression of SV40 T antigen oncoprotein in transgenic mouse β cells, we have shown that reversible immortaliz...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2001-10-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/000000001783986422 |