Repeated Lineage Switches in an Elderly Case of Refractory B-Cell Acute Lymphoblastic Leukemia With MLL Gene Amplification: A Case Report and Literature Review

Repeated Lineage Switches in an Elderly Case of Refractory B-Cell Acute Lymphoblastic Leukemia With MLL Gene Amplification: A Case Report and Literature Review

Lineage switches in acute leukemia occur rarely, and the underlying mechanisms are poorly understood. Herein, we report the case of an elderly patient with leukemia in which the leukemia started as B-cell acute lymphoblastic leukemia (B-ALL) and later changed to B- and T-cell mixed phenotype acute l...

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Bibliographic Details
Main Authors: Reina Takeda, Kazuaki Yokoyama, Tomofusa Fukuyama, Toyotaka Kawamata, Mika Ito, Nozomi Yusa, Rika Kasajima, Eigo Shimizu, Nobuhiro Ohno, Kaoru Uchimaru, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Arinobu Tojo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
lineage switch
B-ALL
AML – acute myeloid leukaemia
MPAL – mixed phenotypic acute leukaemia
MLL
gene amplicaiton
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.799982/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.799982/full

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