Melanoma cells induce dedifferentiation and metabolic changes in adipocytes present in the tumor niche

Abstract Background One of the factors that affect the progression of melanoma is the tumor microenvironment, which consists of cellular elements, extracellular matrix, acidification, and a hypoxic state. Adipocytes are one of the types of cell present in the niche and are localized in the deepest l...

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Bibliographic Details
Main Authors: Aleksandra Simiczyjew, Justyna Wądzyńska, Katarzyna Pietraszek-Gremplewicz, Magdalena Kot, Marcin Ziętek, Rafał Matkowski, Dorota Nowak
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cellular & Molecular Biology Letters
Subjects:
Online Access:https://doi.org/10.1186/s11658-023-00476-3