Cross-protection and cross-neutralization capacity of ancestral and VOC-matched SARS-CoV-2 adenoviral vector-based vaccines

Cross-protection and cross-neutralization capacity of ancestral and VOC-matched SARS-CoV-2 adenoviral vector-based vaccines

Abstract COVID-19 vaccines were originally designed based on the ancestral Spike protein, but immune escape of emergent Variants of Concern (VOC) jeopardized their efficacy, warranting variant-proof vaccines. Here, we used preclinical rodent models to establish the cross-protective and cross-neutral...

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Bibliographic Details
Main Authors: Sabrina E. Vinzón, María V. Lopez, Eduardo G. A. Cafferata, Ariadna S. Soto, Paula M. Berguer, Luciana Vazquez, Leonora Nusblat, Andrea V. Pontoriero, Eduardo M. Belotti, Natalia R. Salvetti, Diego L. Viale, Ariel E. Vilardo, Martin M. Avaro, Estefanía Benedetti, Mara L. Russo, María E. Dattero, Mauricio Carobene, Maximiliano Sánchez-Lamas, Jimena Afonso, Mauro Heitrich, Alejandro E. Cristófalo, Lisandro H. Otero, Elsa G. Baumeister, Hugo H. Ortega, Alexis Edelstein, Osvaldo L. Podhajcer
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00737-4

Internet

https://doi.org/10.1038/s41541-023-00737-4

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