The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice

The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice

We report here the involvement of the stress-responsive glucocorticoid receptor co-chaperone FKBP51 in the mechanism of in vivo secretion of mature BDNF (mBDNF). We used a novel method combining brain microdialysis with a capillary electrophoresis-based immunoassay, to examine mBDNF secretion in the...

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Bibliographic Details
Main Authors: Elmira Anderzhanova, Kathrin Hafner, Andreas J. Genewsky, Azza Soliman, Max L. Pöhlmann, Mathias V. Schmidt, Robert Blum, Carsten T. Wotjak, Nils C. Gassen
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neurobiology of Stress
Subjects:
BDNF
FKBP51
Ketamine
Stress susceptibility
Neuroplasticity
Microdialysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289520300291

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http://www.sciencedirect.com/science/article/pii/S2352289520300291

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