Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis

Nine polyglutamine (polyQ) proteins have already been identified that are considered to be associated with the pathologies of neurodegenerative disorders called polyQ diseases, but whether these polyQ proteins mutually interact and synergize in proteinopathies remains to be elucidated. In this study...

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Bibliographic Details
Main Authors: Hong Jun-Ye, Wang Jian-Yang, Yue Hong-Wei, Zhang Xiang-Le, Zhang Shu-Xian, Jiang Lei-Lei, Hu Hong-Yu
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023081