IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes

IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes

IRSp53 (also known as BAIAP2) is an abundant excitatory postsynaptic scaffolding protein implicated in autism spectrum disorders (ASD), schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). IRSp53 is expressed in different cell types across different brain regions, although it remains...

Full description

Bibliographic Details
Main Authors: Yangsik Kim, Young Woo Noh, Kyungdeok Kim, Esther Yang, Hyun Kim, Eunjoon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
autism
synapse
IRSp53
mPFC
social interaction
hyperactivity
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00023/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00023/full

Similar Items