Historeceptomic fingerprints for drug-like compounds

Most drugs exert their beneficial and adverse effects through their combined action on several different molecular targets (polypharmacology). The true molecular fingerprint of the direct action of a drug has two components: the ensemble of all the receptors upon which a drug acts and their level of...

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Bibliographic Details
Main Authors: Evgeny eShmelkov, Arsen eGrigoryan, James eSwetnam, Junyang eXin, Doreen eTivon, Sergey eShmelkov, Timothy eCardozo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00371/full