ADAM Metalloproteinase Domain 17 Regulates Cholestasis-Associated Liver Injury and Sickness Behavior Development in Mice

ADAM Metalloproteinase Domain 17 Regulates Cholestasis-Associated Liver Injury and Sickness Behavior Development in Mice

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) is a ubiquitously expressed membrane-bound enzyme that mediates shedding of a wide variety of important regulators in inflammation including cytokines and adhesion molecules. Hepatic expression of numerous cytokines and adhesion...

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Bibliographic Details
Main Authors: Wagdi Almishri, Liam A. Swain, Charlotte D’Mello, Tyson S. Le, Stefan J. Urbanski, Henry H. Nguyen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
ADAM17 (a disintegrin and metalloprotease 17)
TACE (TNF-α converting enzyme)
cholestasis
autoimmune liver disease
inflammation
sickness behavior
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.779119/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.779119/full

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