ADAM Metalloproteinase Domain 17 Regulates Cholestasis-Associated Liver Injury and Sickness Behavior Development in Mice

ADAM Metalloproteinase Domain 17 Regulates Cholestasis-Associated Liver Injury and Sickness Behavior Development in Mice

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) is a ubiquitously expressed membrane-bound enzyme that mediates shedding of a wide variety of important regulators in inflammation including cytokines and adhesion molecules. Hepatic expression of numerous cytokines and adhesion...

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Bibliographic Details
Main Authors:	Wagdi Almishri, Liam A. Swain, Charlotte D’Mello, Tyson S. Le, Stefan J. Urbanski, Henry H. Nguyen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Series:	Frontiers in Immunology
Subjects:	ADAM17 (a disintegrin and metalloprotease 17) TACE (TNF-α converting enzyme) cholestasis autoimmune liver disease inflammation sickness behavior
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.779119/full

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