Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1

Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1

Approximately 10% of amyotrophic lateral sclerosis (ALS) cases are familial (known as FALS) with an autosomal dominant inheritance pattern, and ~25% of FALS cases are caused by mutations in Cu/Zn superoxide dismutase (SOD1). There is convincing evidence that mutant SOD1 (mtSOD1) kills motor neurons...

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Bibliographic Details
Main Authors: Ghanashyam D. Ghadge, John D. Pavlovic, Sujatha P. Koduvayur, Brian K. Kay, Raymond P. Roos
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Neurobiology of Disease
Subjects:
Familial amyotrophic lateral sclerosis
Mutant superoxide dismutase type 1
Amyotrophic lateral sclerosis
ALS
Single chain fragments of variable region antibodies
scFvs
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113001216

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http://www.sciencedirect.com/science/article/pii/S0969996113001216

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