High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy

Mitochondrial dysfunction and aberrant mitochondrial homeostasis are key aspects of Parkinson's disease (PD) pathophysiology. Mutations in PINK1 and Parkin proteins lead to autosomal recessive PD, suggesting that defective mitochondrial clearance via mitophagy is key in PD etiology. Acceleratin...

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Bibliographic Details
Main Authors: Roberta Tufi, Emily H. Clark, Tamaki Hoshikawa, Christiana Tsagkaraki, Jack Stanley, Kunitoshi Takeda, James M. Staddon, Thomas Briston
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:SLAS Discovery
Subjects:
High-content screening
Mitophagy
Parkin
Parkinson's disease
PINK1
USP30
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555222137160

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http://www.sciencedirect.com/science/article/pii/S2472555222137160

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