A polymorphism in the cachexia-associated gene INHBA predicts efficacy of regorafenib in patients with refractory metastatic colorectal cancer.

A polymorphism in the cachexia-associated gene INHBA predicts efficacy of regorafenib in patients with refractory metastatic colorectal cancer.

Activin/myostatin signaling has a critical role not only in cachexia but also in tumor angiogenesis. Cachexia is a frequent complication among patients with advanced cancer and heavily pretreated patients. We aimed to evaluate the prognostic significance of cachexia-associated genetic variants in re...

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Bibliographic Details
Main Authors: Yuji Miyamoto, Marta Schirripa, Mitsukuni Suenaga, Shu Cao, Wu Zhang, Satoshi Okazaki, Martin D Berger, Satoshi Matsusaka, Dongyun Yang, Yan Ning, Hideo Baba, Fotios Loupakis, Sara Lonardi, Filippo Pietrantonio, Beatrice Borelli, Chiara Cremolini, Toshiharu Yamaguchi, Heinz-Josef Lenz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0239439

Internet

https://doi.org/10.1371/journal.pone.0239439

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