Modulations of the neuronal trafficking of tissue-type plasminogen activator (tPA) influences glutamate release

Abstract The discovery of the neuronal expression of the serine protease tissue-type plasminogen activator (tPA) has opened new avenues of research, with important implications in the physiopathology of the central nervous system. For example, the interaction of tPA with synaptic receptors (NMDAR, L...

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Bibliographic Details
Main Authors: Alexandre Varangot, Simon Lebatard, Mathys Bellemain-Sagnard, Laurent Lebouvier, Yannick Hommet, Denis Vivien
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05543-9