Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep.

Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep.

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The reduced sleep duration previously observed in Camk2b knockout mice revealed a role for Ca2+/calmodulin-dependent protein kinase II (CaMKII)β as a sleep-promoting kinase. However, the underlying mechanism by which CaMKIIβ supports sleep regulation is largely unknown. Here, we demonstrate that act...

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Bibliographic Details
Main Authors: Daisuke Tone, Koji L Ode, Qianhui Zhang, Hiroshi Fujishima, Rikuhiro G Yamada, Yoshiki Nagashima, Katsuhiko Matsumoto, Zhiqing Wen, Shota Y Yoshida, Tomoki T Mitani, Yuki Arisato, Rei-Ichiro Ohno, Maki Ukai-Tadenuma, Junko Yoshida Garçon, Mari Kaneko, Shoi Shi, Hideki Ukai, Kazunari Miyamichi, Takashi Okada, Kenta Sumiyama, Hiroshi Kiyonari, Hiroki R Ueda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-10-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001813

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https://doi.org/10.1371/journal.pbio.3001813

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