Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation

Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation

Abstract We recently reported an unconventional mechanism by which miRNAs inhibit HIV-1 viral production. This occurs when miRNAs bind nonspecifically to the viral structural protein Gag, interfering with viral RNA-mediated Gag assembly at the plasma membrane. Consequently, misassembled viral comple...

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Bibliographic Details
Main Authors: Na Qu, Zhao Ma, Mengrao Zhang, Muaz N. Rushdi, Christopher J. Krueger, Antony K. Chen
Format: Article
Language:English
Published: Oxford University Press 2017-09-01
Series:Protein & Cell
Subjects:
microRNA
Gag protein
autophagy
Online Access:http://link.springer.com/article/10.1007/s13238-017-0461-z

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http://link.springer.com/article/10.1007/s13238-017-0461-z

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