A DNA/RNA hybrid fluorescent probe for high-throughput quantification of the activity of human apurinic/apyrimidinic endonuclease 1 in subcellular extracts

A DNA/RNA hybrid fluorescent probe for high-throughput quantification of the activity of human apurinic/apyrimidinic endonuclease 1 in subcellular extracts

As a multifunctional DNA repair enzyme, human apurinic/apyrimidinic endonuclease 1 (APE1) plays a pivotal role in many cellular processes. In recent years, it has been recognized as a potential prognostic biomarker and a therapeutic target for many cancers and other diseases. In this work, we report...

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Bibliographic Details
Main Authors: Peng Lu, Xiangjian Cao, Jinghui Zheng, Chenxv Zhu, Ruilan Zhang, Ying Sun, Ziyu Yang, Ziyu Tang, Jiayu Wang, Meiping Zhao
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biosensors and Bioelectronics: X
Subjects:
Apurinic/apyrimidinic endonuclease 1 (APE1)
Abasic site (AP site)
DNA/RNA hybrid
Fluorescent probe
Subcellular extracts
high-throughput quantification
Online Access:http://www.sciencedirect.com/science/article/pii/S2590137023000262

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http://www.sciencedirect.com/science/article/pii/S2590137023000262

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