Mitochondria-Targeting 1,5-Diazacyclooctane-Spacered Triterpene Rhodamine Conjugates Exhibit Cytotoxicity at Sub-Nanomolar Concentration against Breast Cancer Cells

Mitochondria-Targeting 1,5-Diazacyclooctane-Spacered Triterpene Rhodamine Conjugates Exhibit Cytotoxicity at Sub-Nanomolar Concentration against Breast Cancer Cells

1,5-Diazacyclooctane was prepared by a simple synthetic sequence and coupled to pentacyclic triterpenoic acids oleanolic acid, ursolic acid, betulinic acid, platanic acid, and asiatic acid; these amides were activated with oxalyl chloride and reacted with rhodamine B or rhodamine 101 to yield conjug...

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Bibliographic Details
Main Authors: Niels Heise, Selina Becker, Thomas Mueller, Matthias Bache, René Csuk, Antje Güttler
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
asiatic acid
breast cancer
mitocans
rhodamine conjugates
triterpenoic acids
Online Access:https://www.mdpi.com/1422-0067/24/13/10695

Internet

https://www.mdpi.com/1422-0067/24/13/10695

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