17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy
Several types of motorneuron diseases are linked to neurotoxic mutant proteins. These acquire aberrant conformations (misfolding) that trigger deleterious downstream events responsible for neuronal dysfunction and degeneration. The pharmacological removal of misfolded proteins might thus be useful i...
| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Makale |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Elsevier
2011-01-01
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| Seri Bilgileri: | Neurobiology of Disease |
| Online Erişim: | http://www.sciencedirect.com/science/article/pii/S0969996110002950 |