Radiation combined with immune checkpoint inhibitors for unresectable locally advanced non-small cell lung cancer: synergistic mechanisms, current state, challenges, and orientations

Radiation combined with immune checkpoint inhibitors for unresectable locally advanced non-small cell lung cancer: synergistic mechanisms, current state, challenges, and orientations

Abstract Until the advent of immune checkpoint inhibitors (ICIs), definitive radiotherapy (RT) concurrently with chemotherapy was recommended for unresectable, locally advanced non-small cell lung cancer (LA-NSCLC). The trimodality paradigm with consolidation ICIs following definitive concurrent che...

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Bibliographic Details
Main Authors: Leilei Wu, Zhenshan Zhang, Menglin Bai, Yujie Yan, Jinming Yu, Yaping Xu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Cell Communication and Signaling
Subjects:
Locally advanced non-small cell lung cancer (LA-NSCLC)
Radiotherapy
Immune checkpoint inhibitors (ICIs)
RT combined with ICIs (iRT)
Advances
Challenges
Online Access:https://doi.org/10.1186/s12964-023-01139-8

Internet

https://doi.org/10.1186/s12964-023-01139-8

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