Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a subtype of stroke that is characterized by high morbidity and mortality, for which clinical outcome remains poor. An extensive literature indicates that the release of ferrous iron from ruptured erythrocytes in the hematoma is a key pathogenic factor in ICH-induce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.927334/full |
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| author | Zhe Li Zhe Li Zhe Li Yang Liu Yang Liu Yang Liu Ruixue Wei Ruixue Wei Ruixue Wei Suliman Khan Suliman Khan Suliman Khan Ruiyi Zhang Ruiyi Zhang Ruiyi Zhang Yan Zhang Yan Zhang Yan Zhang Voon Wee Yong Mengzhou Xue Mengzhou Xue Mengzhou Xue |
| author_facet | Zhe Li Zhe Li Zhe Li Yang Liu Yang Liu Yang Liu Ruixue Wei Ruixue Wei Ruixue Wei Suliman Khan Suliman Khan Suliman Khan Ruiyi Zhang Ruiyi Zhang Ruiyi Zhang Yan Zhang Yan Zhang Yan Zhang Voon Wee Yong Mengzhou Xue Mengzhou Xue Mengzhou Xue |
| author_sort | Zhe Li |
| collection | DOAJ |
| description | Intracerebral hemorrhage (ICH) is a subtype of stroke that is characterized by high morbidity and mortality, for which clinical outcome remains poor. An extensive literature indicates that the release of ferrous iron from ruptured erythrocytes in the hematoma is a key pathogenic factor in ICH-induced brain injury. Deferoxamine is an FDA-approved iron chelator that has the capacity to penetrate the blood-brain barrier after systemic administration and binds to iron. Previous animal studies have shown that deferoxamine attenuates ICH-induced brain edema, neuronal death, and neurological deficits. This review summarizes recent progress of the mechanisms by which deferoxamine may alleviate ICH and discusses further studies on its clinical utility. |
| first_indexed | 2024-12-12T13:06:50Z |
| format | Article |
| id | doaj.art-bab9f61712bd4664b296e9188950fe00 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-12T13:06:50Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-bab9f61712bd4664b296e9188950fe002022-12-22T00:23:38ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-06-011510.3389/fnmol.2022.927334927334Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral HemorrhageZhe Li0Zhe Li1Zhe Li2Yang Liu3Yang Liu4Yang Liu5Ruixue Wei6Ruixue Wei7Ruixue Wei8Suliman Khan9Suliman Khan10Suliman Khan11Ruiyi Zhang12Ruiyi Zhang13Ruiyi Zhang14Yan Zhang15Yan Zhang16Yan Zhang17Voon Wee Yong18Mengzhou Xue19Mengzhou Xue20Mengzhou Xue21Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaAcademy of Medical Science, Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, ChinaDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaAcademy of Medical Science, Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, ChinaDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaAcademy of Medical Science, Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, ChinaDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaAcademy of Medical Science, Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, ChinaDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaAcademy of Medical Science, Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, ChinaDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaAcademy of Medical Science, Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, ChinaDepartment of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, CanadaDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaAcademy of Medical Science, Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, ChinaIntracerebral hemorrhage (ICH) is a subtype of stroke that is characterized by high morbidity and mortality, for which clinical outcome remains poor. An extensive literature indicates that the release of ferrous iron from ruptured erythrocytes in the hematoma is a key pathogenic factor in ICH-induced brain injury. Deferoxamine is an FDA-approved iron chelator that has the capacity to penetrate the blood-brain barrier after systemic administration and binds to iron. Previous animal studies have shown that deferoxamine attenuates ICH-induced brain edema, neuronal death, and neurological deficits. This review summarizes recent progress of the mechanisms by which deferoxamine may alleviate ICH and discusses further studies on its clinical utility.https://www.frontiersin.org/articles/10.3389/fnmol.2022.927334/fullintracerebral hemorrhagebrain edemadeferoxamineiron overloadneuronal death |
| spellingShingle | Zhe Li Zhe Li Zhe Li Yang Liu Yang Liu Yang Liu Ruixue Wei Ruixue Wei Ruixue Wei Suliman Khan Suliman Khan Suliman Khan Ruiyi Zhang Ruiyi Zhang Ruiyi Zhang Yan Zhang Yan Zhang Yan Zhang Voon Wee Yong Mengzhou Xue Mengzhou Xue Mengzhou Xue Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage Frontiers in Molecular Neuroscience intracerebral hemorrhage brain edema deferoxamine iron overload neuronal death |
| title | Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage |
| title_full | Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage |
| title_fullStr | Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage |
| title_full_unstemmed | Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage |
| title_short | Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage |
| title_sort | iron neurotoxicity and protection by deferoxamine in intracerebral hemorrhage |
| topic | intracerebral hemorrhage brain edema deferoxamine iron overload neuronal death |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.927334/full |
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