Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

The mitochondrial calcium uniporter is a Ca2+-gated ion channel complex that controls mitochondrial Ca2+ entry and regulates cell metabolism. MCU and EMRE form the channel while Ca2+-dependent regulation is conferred by MICU1 and MICU2 through an enigmatic process. We present a cryo-EM structure of...

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Bibliographic Details
Main Authors: Chongyuan Wang, Agata Jacewicz, Bryce D Delgado, Rozbeh Baradaran, Stephen Barstow Long
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
tribolium castaneum
ion channel
calcium channel
toxin
gating
membrane structure
Online Access:https://elifesciences.org/articles/59991

Internet

https://elifesciences.org/articles/59991

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