Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2
The mitochondrial calcium uniporter is a Ca2+-gated ion channel complex that controls mitochondrial Ca2+ entry and regulates cell metabolism. MCU and EMRE form the channel while Ca2+-dependent regulation is conferred by MICU1 and MICU2 through an enigmatic process. We present a cryo-EM structure of...
Main Authors: | Chongyuan Wang, Agata Jacewicz, Bryce D Delgado, Rozbeh Baradaran, Stephen Barstow Long |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/59991 |
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