Tolerability and efficacy of vortioxetine versus SSRIs in elderly with major depression. Study protocol of the VESPA study: a pragmatic, multicentre, open-label, parallel-group, superiority, randomized trial

Tolerability and efficacy of vortioxetine versus SSRIs in elderly with major depression. Study protocol of the VESPA study: a pragmatic, multicentre, open-label, parallel-group, superiority, randomized trial

Abstract Introduction Depression is a highly prevalent condition in the elderly, with a vast impact on quality of life, life expectancy, and medical outcomes. Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed agents in this condition and, although generally safe, toler...

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Main Authors: Giovanni Ostuzzi, Chiara Gastaldon, Angelo Barbato, Barbara D’Avanzo, Mauro Tettamanti, Igor Monti, Andrea Aguglia, Eugenio Aguglia, Maria Chiara Alessi, Mario Amore, Francesco Bartoli, Massimo Biondi, Paola Bortolaso, Camilla Callegari, Giuseppe Carrà, Rosangela Caruso, Simone Cavallotti, Cristina Crocamo, Armando D’Agostino, Pasquale De Fazio, Chiara Di Natale, Laura Giusti, Luigi Grassi, Giovanni Martinotti, Michela Nosé, Davide Papola, Marianna Purgato, Alessandro Rodolico, Rita Roncone, Lorenzo Tarsitani, Giulia Turrini, Elisa Zanini, Francesco Amaddeo, Mirella Ruggeri, Corrado Barbui
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Trials
Subjects:
Randomized clinical trial
Pragmatic trial
Elderly
Antidepressants
Vortioxetine
Depression
Online Access:http://link.springer.com/article/10.1186/s13063-020-04460-6

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http://link.springer.com/article/10.1186/s13063-020-04460-6

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