PI3K/mTOR inhibitor omipalisib prolongs cardiac repolarization along with a mild proarrhythmic outcome in the AV block dog model

PI3K/mTOR inhibitor omipalisib prolongs cardiac repolarization along with a mild proarrhythmic outcome in the AV block dog model

BackgroundThe phosphoinositide 3-kinase (PI3K) signaling pathway is an interesting target in cancer treatment. The awareness of the proarrhythmic risk of PI3K inhibitors was raised because PI3K is also involved in regulating signaling toward cardiac ion channels. Canine cardiomyocytes treated with P...

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Bibliographic Details
Main Authors: J. J. A. van Bavel, C. Pham, H. D. M. Beekman, M. J. C. Houtman, A. Bossu, R. W. Sparidans, M. A. G. van der Heyden, M. A. Vos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
omipalisib
AV block dog model
QT prolongation
PI3K inhibition
ventricular arrhythmia (VA)
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.956538/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.956538/full

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