PIK3CA-Related Overgrowth Spectrum From Diagnosis to Targeted Therapy: A Case of CLOVES Syndrome Treated With Alpelisib

PIK3CA-Related Overgrowth Spectrum From Diagnosis to Targeted Therapy: A Case of CLOVES Syndrome Treated With Alpelisib

PIK3CA-related overgrowth spectrum (PROS) is an umbrella term referring to various clinical entities, which share the same pathogenetic mechanism. These conditions are caused by somatic gain-of-function mutations in PIK3CA, which encodes the 110-kD catalytic α subunit of PI3K (p110α). These PIK3CA m...

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Bibliographic Details
Main Authors: Angelica Pagliazzi, Teresa Oranges, Giovanna Traficante, Chiara Trapani, Flavio Facchini, Alessandra Martin, Alessandro Semeraro, Anna Perrone, Cesare Filippeschi, Sabrina Giglio
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pediatrics
Subjects:
PIK3CA
PROS
CLOVES
Alpelisib/BYL719
targeted (selective) treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.732836/full

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https://www.frontiersin.org/articles/10.3389/fped.2021.732836/full

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