Genomic Profiling of <i>KRAS/NRAS/BRAF/PIK3CA</i> Wild-Type Metastatic Colorectal Cancer Patients Reveals Novel Mutations in Genes Potentially Associated with Resistance to Anti-EGFR Agents

Genomic Profiling of <i>KRAS/NRAS/BRAF/PIK3CA</i> Wild-Type Metastatic Colorectal Cancer Patients Reveals Novel Mutations in Genes Potentially Associated with Resistance to Anti-EGFR Agents

Previous findings suggest that metastatic colorectal carcinoma (mCRC) patients with <i>KRAS/NRAS/BRAF/PIK3CA</i> wild-type (quadruple-wt) tumors are highly sensitive to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs). However, additional molecular alterations m...

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Bibliographic Details
Main Authors: Anna Maria Rachiglio, Matilde Lambiase, Francesca Fenizia, Cristin Roma, Claudia Cardone, Alessia Iannaccone, Antonella De Luca, Marianeve Carotenuto, Daniela Frezzetti, Erika Martinelli, Evaristo Maiello, Fortunato Ciardiello, Nicola Normanno
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
colorectal cancer
anti-EGFR monoclonal antibodies
resistance
genomic profiling
Online Access:https://www.mdpi.com/2072-6694/11/6/859

Internet

https://www.mdpi.com/2072-6694/11/6/859

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