Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue

Difficulty achieving complete, specific, and homogenous staining is a major bottleneck preventing the widespread use of tissue clearing techniques to image large volumes of human tissue. In this manuscript, we describe a procedure to rapidly design immunostaining protocols for antibody labeling of c...

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Bibliographic Details
Main Authors: Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/84112