Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: Thermodynamic modeling
Metformin, as an anti-hyperglycemic, is the main medicine for treating diabetes of type II. However, its daily dose is high due to its incomplete absorption and short half-life, which leads to digestive problems and patient complaints. Controlled release and increased bioavailability of this drug ca...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Case Studies in Thermal Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214157X22008863 |
| _version_ | 1797956261106417664 |
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| author | Kumar Venkatesan Saad M. Alshahrani Amal M. Alsubaiyel Maram H. Abduljabbar Manal E. Alosaimi Maria Grishina Saeed Shirazian |
| author_facet | Kumar Venkatesan Saad M. Alshahrani Amal M. Alsubaiyel Maram H. Abduljabbar Manal E. Alosaimi Maria Grishina Saeed Shirazian |
| author_sort | Kumar Venkatesan |
| collection | DOAJ |
| description | Metformin, as an anti-hyperglycemic, is the main medicine for treating diabetes of type II. However, its daily dose is high due to its incomplete absorption and short half-life, which leads to digestive problems and patient complaints. Controlled release and increased bioavailability of this drug can be achieved using novel drug delivery systems produced with an appropriate supercritical carbon dioxide (scCO2) method. However, the solubility of Metformin in scCO2 is an essential parameter for this purpose which needs to be evaluated prior to the processing. In the current research, solubility of Metformin in scCO2 was determined at temperatures of 308, 318, 328, and 338 K, and pressures of 140, 170, 200, 230, 260, and 290 bar. It was obtained between 0.39 × 10−6 up to 1.23 × 10−6 (mole fraction). Also, the resulting values were correlated through an equation of state (Peng-Robinson (PR-EoS)) and eight well-known empirical correlations (Chrastil, Sung and Shim, Adachi and Lu, Si-Moussa, Bartle, Jafari Nejad, Keshmiri, and Jouyban). The average AARD% value of 8.24 for the PR-EoS model confirmed its satisfactory precision to predict the Metformin solubility in scCO2. Among the mentioned empirical models, the models defined by Jafari Nejad (AARD% of 4.36 and AICc of −997.07) and Keshmiri (AARD% of 4.73 and AICc of −1048.81) show the highest correlation accuracy. Moreover, the total mixing heat, the vaporization enthalpy, and the solvation enthalpies of the Metformin-scCO2 mixture were computed. |
| first_indexed | 2024-04-10T23:46:15Z |
| format | Article |
| id | doaj.art-bacaf8ede595428889e75d7930c7056e |
| institution | Directory Open Access Journal |
| issn | 2214-157X |
| language | English |
| last_indexed | 2024-04-10T23:46:15Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Studies in Thermal Engineering |
| spelling | doaj.art-bacaf8ede595428889e75d7930c7056e2023-01-11T04:29:19ZengElsevierCase Studies in Thermal Engineering2214-157X2023-01-0141102649Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: Thermodynamic modelingKumar Venkatesan0Saad M. Alshahrani1Amal M. Alsubaiyel2Maram H. Abduljabbar3Manal E. Alosaimi4Maria Grishina5Saeed Shirazian6Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, 62529, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj, 11942, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah, 52571, Saudi Arabia; Corresponding author.Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, 21944, Saudi ArabiaDepartment of Basic Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, 11671, Saudi ArabiaLaboratory of Computational Modeling of Drugs, South Ural State University, 76 Lenin Prospekt, 454080, Chelyabinsk, RussiaLaboratory of Computational Modeling of Drugs, South Ural State University, 76 Lenin Prospekt, 454080, Chelyabinsk, RussiaMetformin, as an anti-hyperglycemic, is the main medicine for treating diabetes of type II. However, its daily dose is high due to its incomplete absorption and short half-life, which leads to digestive problems and patient complaints. Controlled release and increased bioavailability of this drug can be achieved using novel drug delivery systems produced with an appropriate supercritical carbon dioxide (scCO2) method. However, the solubility of Metformin in scCO2 is an essential parameter for this purpose which needs to be evaluated prior to the processing. In the current research, solubility of Metformin in scCO2 was determined at temperatures of 308, 318, 328, and 338 K, and pressures of 140, 170, 200, 230, 260, and 290 bar. It was obtained between 0.39 × 10−6 up to 1.23 × 10−6 (mole fraction). Also, the resulting values were correlated through an equation of state (Peng-Robinson (PR-EoS)) and eight well-known empirical correlations (Chrastil, Sung and Shim, Adachi and Lu, Si-Moussa, Bartle, Jafari Nejad, Keshmiri, and Jouyban). The average AARD% value of 8.24 for the PR-EoS model confirmed its satisfactory precision to predict the Metformin solubility in scCO2. Among the mentioned empirical models, the models defined by Jafari Nejad (AARD% of 4.36 and AICc of −997.07) and Keshmiri (AARD% of 4.73 and AICc of −1048.81) show the highest correlation accuracy. Moreover, the total mixing heat, the vaporization enthalpy, and the solvation enthalpies of the Metformin-scCO2 mixture were computed.http://www.sciencedirect.com/science/article/pii/S2214157X22008863MetforminSupercritical carbon dioxideSolubilityCorrelationThermodynamic model |
| spellingShingle | Kumar Venkatesan Saad M. Alshahrani Amal M. Alsubaiyel Maram H. Abduljabbar Manal E. Alosaimi Maria Grishina Saeed Shirazian Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: Thermodynamic modeling Case Studies in Thermal Engineering Metformin Supercritical carbon dioxide Solubility Correlation Thermodynamic model |
| title | Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: Thermodynamic modeling |
| title_full | Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: Thermodynamic modeling |
| title_fullStr | Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: Thermodynamic modeling |
| title_full_unstemmed | Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: Thermodynamic modeling |
| title_short | Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: Thermodynamic modeling |
| title_sort | experimental theoretical approach for determination of metformin solubility in supercritical carbon dioxide thermodynamic modeling |
| topic | Metformin Supercritical carbon dioxide Solubility Correlation Thermodynamic model |
| url | http://www.sciencedirect.com/science/article/pii/S2214157X22008863 |
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