Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline

Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline

Background: Myoprotein degradation accelerates in obese individuals, resulting in a decline in muscular mass. Atg7 plays a crucial role in regulating protein stability and function through both autophagy-dependent and independent pathways. As obesity progresses, the expression of Atg7 gradually rise...

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Bibliographic Details
Main Authors: Yang Yu, Jing Yang, Lixia Zheng, Han Su, Sunrun Cao, Xuehan Jiang, Xiyan Liu, Weiwei Liu, Zhuo Wang, Fang Meng, Hongde Xu, Deliang Wen, Chen Sun, Xiaoyu Song, Antonio Vidal-Puig, Liu Cao
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Metabolism
Subjects:
Obesity
Insulin resistance
Muscular mass decline
Atg7
FoxO3a
Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000231

Internet

http://www.sciencedirect.com/science/article/pii/S2212877824000231

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