Modulation of Regulatory T Cells Activity by Distinct CD80 and CD86 Interactions With CD28/CTLA-4 in Chagas Cardiomyopathy

Modulation of Regulatory T Cells Activity by Distinct CD80 and CD86 Interactions With CD28/CTLA-4 in Chagas Cardiomyopathy

Chagas cardiomyopathy is the symptomatic cardiac clinical form (CARD) of the chronic phase of Chagas disease caused by Trypanosoma cruzi infection. It was described as the most fibrosing cardiomyopathies, affecting approximately 30% of patients during the chronic phase. Other less frequent symptomat...

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Main Authors: Bruna F. Pinto, Nayara I. Medeiros, Andrea Teixeira-Carvalho, Jacqueline A. Fiuza, Silvana M. Eloi-Santos, Maria C. P. Nunes, Silvana A. Silva, Tereza C. M. Fontes-Cal, Mayara Belchior-Bezerra, Walderez O. Dutra, Rodrigo Correa-Oliveira, Juliana A. S. Gomes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Chagas disease
CD80 co-stimulatory molecule
Treg cells
immune response
Chagas cardiomyopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.750876/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.750876/full

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