Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria

Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria

Antigens (Ags) with multivalent and repetitive structure elicit IgG production in a T-cell-independent manner. However, the mechanisms by which such T-cell-independent type-2 (TI-2) Ags induce IgG responses remain obscure. Here, we report that B-cell receptor (BCR) engagement with a TI-2 Ag but not...

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Bibliographic Details
Main Authors: Saori Fukao, Kei Haniuda, Hiromasa Tamaki, Daisuke Kitamura
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
immune response
B cells
TI-2
class switching
Online Access:https://elifesciences.org/articles/72116

Internet

https://elifesciences.org/articles/72116

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