Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes

Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes

Abstract Background Glioblastoma (GBM) has one of the worst 5-year survival rates of all cancers. While genomic studies of the disease have been performed, alterations in the non-coding regulatory regions of GBM have largely remained unexplored. We apply whole-genome sequencing (WGS) to identify non...

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Bibliographic Details
Main Authors: Sharadha Sakthikumar, Ananya Roy, Lulu Haseeb, Mats E. Pettersson, Elisabeth Sundström, Voichita D. Marinescu, Kerstin Lindblad-Toh, Karin Forsberg-Nilsson
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Genome Biology
Subjects:
Glioblastoma
Cancer
Non-coding constraint
Gene regulation
Online Access:http://link.springer.com/article/10.1186/s13059-020-02035-x

Internet

http://link.springer.com/article/10.1186/s13059-020-02035-x

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