A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach

A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach

An in silico study has been conducted upon (3′<i>RS</i>,5′<i>SR</i>)-5-[2′-benzyl-5′-hydroxymethyl-1′,2′-isoxazolidin-3′-yl]uracil through a molecular dynamics/docking approach that highlights its potential inhibitory activity upon the wild-type pseudouridine 5′-monophosphate...

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Bibliographic Details
Main Authors: Giuseppe Floresta, Venerando Pistarà, Kirsten E. Christensen, Emanuele Amata, Agostino Marrazzo, Davide Gentile, Antonio Rescifina, Francesco Punzo
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
pseudouridine
pseudouridine 5′-monophosphate glycosidase
isoxazolidine analogs
crystal morphology
polymorphic forms
Online Access:https://www.mdpi.com/1420-3049/23/12/3381

Internet

https://www.mdpi.com/1420-3049/23/12/3381

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