Klotho Inhibits Unilateral Ureteral Obstruction-Induced Endothelial-to-Mesenchymal Transition via TGF-β1/Smad2/Snail1 Signaling in Mice

Klotho Inhibits Unilateral Ureteral Obstruction-Induced Endothelial-to-Mesenchymal Transition via TGF-β1/Smad2/Snail1 Signaling in Mice

This study aimed to evaluate repression of Klotho on unilateral ureteral obstruction (UUO)-induced renal fibrosis and endothelial-to-mesenchymal transition (EndoMT) in mice. Renal fibrosis model was established by UUO in C57BL/6 male mice. Recombinant Klotho protein was administered to UUO mice as t...

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Bibliographic Details
Main Authors: Shasha Li, Lixia Yu, Aolin He, Qifeng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
Klotho
unilateral ureteral obstruction
endothelial-mesenchymal transition
transforming growth factor-β1
Snail1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00348/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00348/full

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