Personalized neoantigen-based T cell therapy triggers cytotoxic lymphocytes expressing polyclonal TCR against metastatic ovarian cancer

Personalized neoantigen-based T cell therapy triggers cytotoxic lymphocytes expressing polyclonal TCR against metastatic ovarian cancer

Neoantigen-reactive cytotoxic T lymphocytes play a vital role in precise cancer cell elimination. In this study, we demonstrate the effectiveness of personalized neoantigen-based T cell therapy in inducing tumor regression in two patients suffering from heavily-burdened metastatic ovarian cancer. Ou...

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Bibliographic Details
Main Authors: Shuen-Iu Hung, Mu-Tzu Chu, Ming-Mo Hou, Yun-Shien Lee, Chan-Keng Yang, Sung-Yu Chu, Feng-Yuan Liu, Hung-Chih Hsu, Shih-Cheng Pao, Yu-Chuan Teng, Chun-Bing Chen, Angel Chao, Wen-Hung Chung, John Wen-Cheng Chang, Chyong-Huey Lai
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Neoantigen
Cell therapy
Cytotoxic T lymphocytes
T cell receptor (TCR)
Personalized medicine
Ovarian cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223017262

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http://www.sciencedirect.com/science/article/pii/S0753332223017262

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