PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles

PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles

Highlights 1. CuONPs disturb mitochondrial dynamics and trigger mitophagy in vascular endothelial cells and mouse blood vessel. 2. PINK1/TAX1BP1-mediated mitophagy regulates the removal of excessive ROS and aberrant mitochondria in CuONPs-treated vascular endothelial cells. 3. The mitophagy activato...

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Bibliographic Details
Main Authors: Yinzhen Fan, Zhenli Cheng, Lejiao Mao, Ge Xu, Na Li, Mengling Zhang, Ping Weng, Lijun Zheng, Xiaomei Dong, Siyao Hu, Bin Wang, Xia Qin, Xuejun Jiang, Chengzhi Chen, Jun Zhang, Zhen Zou
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Nanobiotechnology
Subjects:
CuONPs
Vascular endothelial injury
Mitophagy
PINK1/TAX1BP1
Urolithin A
Online Access:https://doi.org/10.1186/s12951-022-01338-4

Internet

https://doi.org/10.1186/s12951-022-01338-4

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