HLA-DQ B1*0201 and A1*0102 alleles are not responsible of antituberculosis drugs induced hepatotoxicity risk in Spanish population

HLA-DQ B1*0201 and A1*0102 alleles are not responsible of antituberculosis drugs induced hepatotoxicity risk in Spanish population

Aims: To evaluate the role of HLA class II DQB1*0201 and DQA1*0102 in the risk of antituberculosis drug-induced hepatotoxicity in a cohort of tuberculosis patients of Caucasian origin from Spain.Methods: Matched case-control study including active tuberculosis (TB) patients from Spain (Caucasian) tr...

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Bibliographic Details
Main Authors: VIRGINIA LEIRO-FERNÁNDEZ, Diana Valverde, Rafael Vazquez-Gallardo, Lucia Constenla-Caramés, Victor del Campo-Pérez, Alberto Fernández-Villar
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Medicine
Subjects:
Hepatitis
DQB1*0201
DQA1*0102
pharmacogenetics susceptibility
first line antituberculosis drugs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmed.2016.00034/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmed.2016.00034/full

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